1What is Profilo?

Profhilo is a biotechnological skin resurfacing product based on pure hyaluronic acid, first developed and introduced to the market by the Italian company IBSA. Unlike conventional fillers, Profhilo is not designed to create volume or change the shape of the face; its main purpose is to deeply hydrate, stimulate the production of collagen and elastin, and improve the overall quality of the skin . The product is commonly known by the trade name "Profilo" but is also described in the scientific literature as "Hybrid Cooperative Complexes of Hyaluronic Acid".

Profilo is the world's first approved bio-remodeling treatment; instead of filling a specific line or crease, it rebuilds the skin's internal structure from the ground up, leaving a "natural and uniform" effect on the entire treated area.

2Mechanism of action and the science behind Profilo

Unique combination

Each syringe of Profhilo contains 64 mg of pure hyaluronic acid in 2 ml; a 50/50 blend of high molecular weight (1000-1400 kDa) and low molecular weight (80-100 kDa) hyaluronic acid. The two forms are bonded together by thermal bonding (without additional chemicals such as BDDE).

Abin-Rahba (Slow & Fast Release)

• Phase 1 (first 24 hours): The lightweight hyaluronic component quickly provides deep hydration in the dermis layer and locks moisture into the skin.
• Phase 2 (days to weeks): The high molecular weight form is slowly released and stimulates fibroblast receptors (CD44 and RHAMM) to enhance the production of collagen type 1, type 4, and elastin .
• Anti-free radical properties: Profhilo inhibits the activity of free radicals and slows down the oxidative process and skin aging.

Another important feature is the fluid and spreading behavior of this gel: Profhilo spreads into the tissue after injection and does not remain as a lump or bump like fillers; therefore, there is almost no risk of asymmetry or unnatural volume.

3The difference between Profilo and fillers and mesotherapy

For this reason, Profilo is known as a “natural complementary or alternative treatment to fillers,” especially for people who are afraid of the artificial look of fillers but want real rejuvenation.

4Applications and areas that can be treated

The most famous application of Profilo is the "five-point" facial rejuvenation (BAAP Technique), which is explained below.

5Suitable and unsuitable candidates

Suitable candidate

• People over 30 with early signs of aging, dehydration, and decreased skin integrity
• People with mild to moderate sagging of the face, neck, or body
• Those who want a natural look and avoid filler volume
• People who have recently had fillers removed and improving skin quality is a priority for them
• Athletes with low fat mass who have sagging faces

Unsuitable candidate

• Having severe skin laxity (in these cases, surgical procedures or a facelift are more appropriate)
• Known sensitivity to hyaluronic acid or history of anaphylactic shock
• Active skin infection, inflammation, or active herpes at the injection site
• Pregnancy and lactation (due to lack of adequate safety studies)
• Active autoimmune diseases or taking medications that weaken the immune system
• Recent vaccination history (2 weeks interval is usually recommended)

6Steps for performing a Profilo injection

Standard 5-point BAAP technique

Appropriate injection technique in other areas

• Neck: 5 dots in two parallel vertical lines
• Décolleté: Injection at symmetrical points on both sides of the midline
• Back of hand: 10 points (5 points on each hand) evenly distributed
• Arm, abdomen, thigh: grid pattern similar to the face with a distance of about 2 cm

7Pre-injection care

• Avoid taking anticoagulants and nonsteroidal anti-inflammatory drugs (after consulting with your doctor) for a week before the procedure to reduce the risk of bruising.
• Avoid alcohol and smoking for 24 hours beforehand.
• If you have a history of herpes, talk to your doctor before your appointment; antiviral prophylaxis may be necessary.
• On the day of the appointment, come without makeup and with clean skin.
• Avoid laser, microdermabrasion, or chemical peels in the immediate vicinity of the session.

8Post-injection care

The first 24 hours

• Avoid touching, massaging, or applying makeup to the injection area.
• Avoid strenuous exercise, saunas, swimming pools, and extreme heat.
• Mild bruising or swelling at the injection sites is normal and will resolve within 24 to 48 hours.
• The use of cold compresses (moderately and gently) is allowed to reduce swelling.

Up to a week

• Use sunscreen with an SPF of 30 or higher daily.
• Use gentle moisturizers and non-irritating products.
• Avoid thermal events (sauna, steam, direct sunlight).
• Limit alcohol and smoking to speed up the healing process.

9Possible complications and ways to prevent them

Common and transient side effects

• Mild redness, swelling, and tenderness at injection sites (usually less than 48 hours)
• Small bruise at the needle site (normal and will fade within a few days)
• A lump or lumpy feeling at the injection site that will subside within 24 hours

Rare complications

• Allergic reaction to hyaluronic acid (very rare due to its pure, BDDE-free nature)
• Bacterial infection if sterile conditions are not observed
• Delayed inflammatory granuloma or nodule
• Vascular damage (in unprofessional and inappropriate injections)

10Treatment period and number of sessions

For the neck and décolleté, 2 ml per session is usually sufficient, and for the back of the hands, about 1 ml per hand; the exact dosage is determined by the doctor based on the size of the area and the quality of the skin.

11Results and durability

• Days 1 to 3: Noticeable hydration, clarity, and radiance of the skin
• Week 2 onwards: Improved skin elasticity and firmness due to collagen stimulation
• Weeks 4 to 8: Peak results; reduction of fine lines, improvement of mild sagging, and even skin tone
• Durability: Usually 6 months (can be maintained for up to 9 to 12 months with restorative sessions)

Factors such as age, basic skin quality, lifestyle (smoking, nutrition, sleep), amount of sun exposure, and compliance with aftercare have a direct impact on the intensity and durability of results.

12Profilo in different areas of the body

Profilo Body (Body Profile)

For larger areas of the body, such as the abdomen, arms, thighs, and knees, a proprietary formulation called "Profilo Body" is designed, which is offered in larger syringes and is used for sagging after pregnancy, severe weight loss, or aging.

Profilo in men

In men, the injection pattern is slightly different due to thicker skin and the presence of a beard; however, similar results are achieved, including firmness, hydration, and reduction of sagging.

13Comparison with other rejuvenation methods

• Profilo vs. Botox: Botox is muscular in nature and eliminates movement lines; Profilo improves skin quality. A combination of the two often gives a balanced result.
• Profilo vs. Microdermabrasion and Peeling: These procedures target the surface of the skin; Profilo rebuilds and complements them from deep within the dermis.
• Profilo vs. RF and Ultrasonic: Energy-based methods are best suited for moderate to severe sagging; Profilo is best for mild sagging and improving skin quality.
• Profhilo vs. Hyaluronic Mesotherapy: Profhilo has a much higher concentration, stronger collagen stimulation, and longer lasting effect.

14Frequently Asked Questions

15Conclusion

Profilo injections are a non-invasive, safe and evidence-based treatment for skin quality restoration, deep hydration and collagen and elastin stimulation. With the standard 5-point BAAP protocol, two main sessions 4 weeks apart and 6-month maintenance sessions, natural and lasting results are achieved; without the artificial appearance or inappropriate volumization.

The success of the treatment depends on three factors: choosing an experienced specialist, using an original product, and carefully following pre- and post-injection care . Before starting treatment, be sure to seek professional advice to determine the injection points and dosage appropriate to your skin condition.